Research Associate Position – Structure-based protein engineering – Hospital for Sick Children Research Institute, Toronto, Canada
Dr. Julien’s laboratory at The Hospital for Sick Children Research Institute (https://lab.research.sickkids.ca/julien/) is looking for a Computational Biologist to join our Structural Immunology team as a Research Associate. The successful candidate will participate in the design and engineering of antigens and antibodies in our quest to develop effective immunogens and immunotherapies. We are looking for a driven, enthusiastic and experienced scientist who demonstrates passion and creativity towards the structure/function study of important pathogenic targets and who can thrive in a highly-collaborative setting.
Roles & Responsibilities
* Use computational biology approaches to design and optimize proteins from available antibody-antigen crystal structures;
* Apply computational biology to engineer protein nanoparticles with optimal delivery properties;
* Interact across research teams to enhance computational biology applications related to vaccine design and antibody therapeutic development;
* Coordinate projects with international collaborators, including timely presentation of results and joint writing of reports.
Desired Skills and Experience
* Computational/Structural Biologist with a PhD in Biochemistry, Computational Biology, Molecular Biology, Immunology, or related field. Post-doctoral experience is a plus;
* Demonstrated ability to participate in collaborative and productive scientific projects;
* Organization skills, efficiency and meticulous record keeping;
* Experience in supervising and mentoring junior members of a research team;
* Practical experience in using protein evolution or yeast/mammalian display approaches to improve antibody-antigen binding interfaces is a plus;
* Strong knowledge of using structural biology to study pathogens, especially in a context of structure-based vaccine design is a plus;
* Experience in molecular biology, protein expression in various systems, purification and biophysical characterization is a plus.
How to Apply?
Send your CV and a letter of intent to [email protected] before Nov 20th 2017. Successful candidates will be notified for interviews, at which time two letters of references will also be required. Anticipated start date is early 2018.
Dr. Julien’s laboratory is interested in the structure/function study of B cell receptors and antibody interactions with antigens. A better understanding of the structures of B cell surface molecules and their secreted antibodies will serve towards the rational design of improved vaccine immunogens against a variety of pathogens, including malaria and HIV-1. Structure-based design is also applied to optimize antibody therapeutics to deplete dysregulated B cells in blood cancers and autoimmune disorders. Dr. Julien’s laboratory is located in The Peter Gilgan Centre for Research and Learning, a new 21-story, 750,000 square-foot facility that incorporates an open-concept design, state-of-the-art research facilities, and collaborative work spaces. As a member of the SickKids community, you will become part of a world-renowned organization dedicated to fulfilling a vision of Healthier Children, A Better World. For over 135 years, SickKids has worked hard to make the world a better place for children and their families. Each day, people around the organization are doing meaningful work that directly, and often indirectly, benefits children in Canada and around the world.